Thanks to what's dubbed as the "Renown Gene", for the last eighty years heroes and villians have become a natural part of life. The origins of the Renown Gene are not known to the majority of the public, instead most believe that some people are just born with it and some are not, while in reality it is the result of higher beings mating with humans thousands of years ago as this verse from the Bible explains.

Genesis 6:4 "The Nephilim were on the earth in those days, and also afterward, when the sons of God came in to the daughters of man and they bore children to them. These were the mighty men who were of old, the men of renown."

(Hence the series title: Those of Renown)

In present time Major heroes are enlisted by a company called Mirador industries, they have managers and agents who look out for their public images while other lesser heroes work illegally as vigilantes. Mirador industries is a company that proclaims their objective is to keep the peace within the country, while their true, hidden goals are control and new world order.

The story first begins revolving around Lance Cohen, who moves into a new apartment with his long time friend after graduating from University. Lance has the power to teleport and although he has always wanted to become a hero he puts it off due to a childhood incident that resulted in his older brother's death while accidentally using his powers.

Mirador Industries's top hero "Battalion" announces that he will for the first time ever, be hosting tryouts to the public for the chance to become part of his five person team. This intrigues Lance, believing that this may be his opportunity to become what he's always wanted.

While still hesitant to try out, Sam, Battalion's manager happens to see Lance saving a couple from certain death with his teleportation powers, in which Sam urges Lance to try out to become a part of Battalion's team, mentioning to Lance that he is actually Battalion's manager. Due to the fact that Lance can't fully control his powers Sam tells Lance that if he decides to try out he will help him train to better control them. Lance agrees the next day and his training begins. The story then begins to focus on not just Lance but the other four individuals who seek to become a part of Battalion's team. Lance along with the other four eventually try out and successfully become part of Battalion's team.

While uncovering the intentions of a secret company known as " The Redress" (who the public perceives as a villain organization) Lance and the other four heroes begin to find out that the company they work for also may not have transparent intentions. The series first season comes to an end when Lance finds out that his older brother who he thought he accidentally killed in their childhood is actually alive and one of the leaders of The Redress, but he mysteriously has no memory of Lance.

The overall premise of the story is a group of five individuals uncovering a thrilling mystery of their existence and their suspected, eventual end, finding out what it really means to be a hero while at the same time learning the lengths organizations will go to bring their ambitions to fruition.